Beta-Lactam Resistance Profile of E. Coli Isolated from Urinary Tract Infection Patients in Selected Hospitals within Gusau Metropolis

Authors

  • Jafar Usman Federal University Gusau, Zamfara State, Nigeria
  • Ahmad Balarabe Hamza Federal University Gusau, Nigeria.
  • Abubakar Abdullahi Federal University Gusau, Nigeria,
  • Mustapha Sani Federal University Gusau, Nigeria.
  • Rasheeda Muhammed Federal University Gusau, Nigeria,
  • Asmau Abdullahi Federal University Gusau, Nigeria.
  • Khadijatu Zakari Federal University Gusau, Nigeria.
  • Usman Hadi Abubakar Federal University Gusau, Nigeria.
  • Nurudeen Salisu Federal University Gusau, Nigeria
  • Shehu Abdullahi Zamfara State University, Talata Mafara, Nigeria
  • Sadisu Ahmed Muhammad Zamfara State University, Talata Mafara, Nigeria
  • Bilya Bashir Zamfara State University, Talata Mafara, Nigeria
  • Bara’atu Isah Moriki Zamfara State University, Talata Mafara, Nigeria
  • Shafa’atu Ahmad Oyeeza Zamfara State University, Talata Mafara, Nigeria
  • Umar Bala Zamfara State University, Talata Mafara, Nigeria
  • Muazu Aliyu Gada Usmanu Danfodiyo University Sokoto, Nigeria.
  • Abdulkadir Ahmad Usmanu Danfodiyo University Sokoto, Nigeria
  • Sadiq Musa Federal University Birnin Kebbi, Nigeria

DOI:

https://doi.org/10.57233/ijsgs.v9i1.618

Keywords:

UTIs, ESBL, E. coli, beta-lactam, Prevalence

Abstract

The emergence of antibiotic resistance, particularly beta-lactam resistance, poses a significant challenge in the management of urinary tract infections (UTIs) caused by Escherichia coli (E. coli). This study aimed to investigate the beta-lactam resistance profile of E. coli isolated from UTI patients in selected hospitals within the Gusau metropolis. A total of 92 urine samples were collected from UTI patients attending selected hospitals in Gusau metropolis. Isolation and identification of E. coli were conducted using standard microbiological techniques. Antibiotic susceptibility testing was performed using the disc diffusion method according to Clinical and Laboratory Standards Institute (CLSI) guidelines. Furthermore, phenotypic confirmation of beta-lactam resistance was carried out using double disc synergy testing (DDST).  Out of 92 urine samples obtained from patients with UTIs, E. coli was identified in 19 samples (20.7%), out of the 19 E. coli isolates, ESBL production was detected in 9 (47.36%) based on the results of the DDST, and among the E. coli isolates tested, 12 (63.16%) exhibited resistance to beta-lactam (Ceftriaxone), while 5 (26.31%) showed intermediate susceptibility, and 2 (10.53%) were susceptible to this antibiotic. Results revealed a concerning prevalence of beta-lactam resistance among E. coli isolates, highlighting the urgent need for effective antimicrobial stewardship and infection control measures in the region.

Author Biographies

Jafar Usman, Federal University Gusau, Zamfara State, Nigeria

Department of Biochemistry,

Federal University Gusau, Nigeria,

Ahmad Balarabe Hamza, Federal University Gusau, Nigeria.

Department of Biochemistry,

Federal University Gusau, Nigeria,

Abubakar Abdullahi, Federal University Gusau, Nigeria,

Department of Biochemistry,

Federal University Gusau, Nigeria,

Mustapha Sani, Federal University Gusau, Nigeria.

Department of Biochemistry,

Federal University Gusau, Nigeria,

Rasheeda Muhammed, Federal University Gusau, Nigeria,

Department of Biochemistry, Federal University Gusau, Nigeria,

Asmau Abdullahi, Federal University Gusau, Nigeria.

Department of Biochemistry, Federal University Gusau, Nigeria,

Khadijatu Zakari, Federal University Gusau, Nigeria.

Department of Biochemistry, Federal University Gusau, Nigeria,

Usman Hadi Abubakar, Federal University Gusau, Nigeria.

Department of Biochemistry, Federal University Gusau, Nigeria,

Nurudeen Salisu, Federal University Gusau, Nigeria

Department of Microbiology, Federal University Gusau, Nigeria

Shehu Abdullahi, Zamfara State University, Talata Mafara, Nigeria

Department of Biochemistry, Zamfara State University, Talata Mafara, Nigeria

Sadisu Ahmed Muhammad, Zamfara State University, Talata Mafara, Nigeria

Department of Biochemistry, Zamfara State University, Talata Mafara, Nigeria

Bilya Bashir, Zamfara State University, Talata Mafara, Nigeria

Department of Biochemistry, Zamfara State University, Talata Mafara, Nigeria

Bara’atu Isah Moriki, Zamfara State University, Talata Mafara, Nigeria

Department of Biochemistry, Zamfara State University, Talata Mafara, Nigeria

Shafa’atu Ahmad Oyeeza, Zamfara State University, Talata Mafara, Nigeria

Department of Biochemistry, Zamfara State University, Talata Mafara, Nigeria

Umar Bala, Zamfara State University, Talata Mafara, Nigeria

Department of Biochemistry, Zamfara State University, Talata Mafara, Nigeria

Muazu Aliyu Gada, Usmanu Danfodiyo University Sokoto, Nigeria.

Department of Biochemistry,

Usmanu Danfodiyo University Sokoto, Nigeria.

Abdulkadir Ahmad, Usmanu Danfodiyo University Sokoto, Nigeria

Department of Biochemistry,

Usmanu Danfodiyo University Sokoto, Nigeria

Sadiq Musa, Federal University Birnin Kebbi, Nigeria

Department of Biochemistry,

Federal University Birnin Kebbi, Nigeria

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Published

2023-03-31

How to Cite

Usman, J. ., Hamza, A. B. ., Abdullahi, A. ., Sani, M. ., Rasheeda , R. ., Abdullahi, A. ., Zakari, K. ., Abubakar, U. H. ., Salisu, N. ., Abdullahi, S. ., Muhammad, S. A. ., Bashir, B. ., Moriki, B. I. ., Oyeeza, S. A. ., Bala, U. ., Gada, M. A. ., Ahmad, A. ., & Sadiq Musa, S. M. (2023). Beta-Lactam Resistance Profile of E. Coli Isolated from Urinary Tract Infection Patients in Selected Hospitals within Gusau Metropolis. International Journal of Science for Global Sustainability, 9(1), 171–176. https://doi.org/10.57233/ijsgs.v9i1.618