In-Vivo Antivenom Effect of Annona senegalensis (Pers) Against Biological Activities of Naja nigricollis (Hallowell) Envenomation

Authors

  • Idris Aliyu Kankara Federal Polytechnic Kaura Namoda, Zamfara State, Nigeria.
  • Aliyu Abdullahi Maru Department of Science Laboratory Technology, Federal Polytechnic Kaura Namoda, Zamfara State, Nigeria.
  • Gayus Aminu Paulina Federal Polytechnic Kaura Namoda, Zamfara State, Nigeria.
  • Binta G. Kurfi Department of Biochemistry, Faculty of Biomedical Science Bayero University, Kano

DOI:

https://doi.org/10.57233/ijsgs.v9i3.530

Keywords:

Annona senegalensis (Pers), Naja nigricollis (Hallowell.), Envenomation, Biological activities.

Abstract

Snake bites are a common, serious medical issue often neglected in developing countries. This study aims to investigate the effectiveness of methanolic extract from the root bark of Annona senegalensis in neutralizing the biological activities of Naja nigricollis envenomation in vivo. The methanolic extract was fractionated using a liquid-liquid fractionating method. The inhibition of venom-induced edematogenic and hemorrhagic effects was evaluated in albino rats using a pre-incubation protocol. The aqueous-methanol fraction (AM) of A. senegalensis AM root methanolic extract significantly inhibited the hemorrhagic and edema-inducing activities of the venom. The methanolic extract derived from the root bark of A. senegalensis has exhibited promising potential as an effective anti-snake venom agent.

Author Biographies

Idris Aliyu Kankara, Federal Polytechnic Kaura Namoda, Zamfara State, Nigeria.

Department of Science Laboratory Technology, Federal Polytechnic Kaura Namoda, Zamfara State, Nigeria.

Aliyu Abdullahi Maru, Department of Science Laboratory Technology, Federal Polytechnic Kaura Namoda, Zamfara State, Nigeria.

Department of Science Laboratory Technology,

Federal Polytechnic Kaura Namoda,

Zamfara State, Nigeria.

Gayus Aminu Paulina, Federal Polytechnic Kaura Namoda, Zamfara State, Nigeria.

Department of Science Laboratory Technology,

Federal Polytechnic Kaura Namoda,

Zamfara State, Nigeria.

Binta G. Kurfi, Department of Biochemistry, Faculty of Biomedical Science Bayero University, Kano

 Department of Biochemistry,

Faculty of Biomedical Science

Bayero University, Kano

Nigeria,

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Published

2023-10-31

How to Cite

Kankara, I. A. ., Maru, A. A. ., Paulina, G. A. ., & Kurfi, B. G. . (2023). In-Vivo Antivenom Effect of Annona senegalensis (Pers) Against Biological Activities of Naja nigricollis (Hallowell) Envenomation. International Journal of Science for Global Sustainability, 9(3), 70–78. https://doi.org/10.57233/ijsgs.v9i3.530

Issue

Vol. 9 No. 3 (2023): INTERNATIONAL JOURNAL OF SCIENCE FOR GLOBAL SUSTAINABILITY

Section

Articles

License

Copyright (c) 2023 Author(s)

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This work is licensed under a Creative Commons Attribution 4.0 International License.